This is processed Dissolved Inorganic Carbon (DIC) and Total Alkalinity (TA) data from the Integrated Ecosystem Programme cruise in the Southern Benguela (IEP-SB). The cruise took place from 23 to 29 May 2017 aboard the RV Algoa. A total of 25 stations were occupied along four transect lines on the west coast of South Africa and additional stations where a red tide was crossed. Five Conductivity, Temperature, Depth (CTD) stations were occupied along the Kleinsee Monitoring Line (KML) of Kleinsee, six along the Namaqua Monitoring Line (NML) of Namaqua, seven stations along the St Helena Bay Monitoring Line (SHBML), two separate stations in the low oxygen zone in St Helena Bay, and five stations along the Scarborough Monitoring Line (SCL) of Cape Columbine. Discrete water samples were collected in 500ml Certified Reference Materials (CRM) bottles from Niskin bottles and spiked with 0,02% of Mercuric chloride before being stored in the dark at room temperature for later analysis in...